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An ensemble of mathematical model is presented that all show diauxic growth behaviour of a bacterial culture.
Carbon catabolite repression (CCR) is the main mechanism controlling
carbohydrate uptake in bacteria, and therefore also controlling
whether or not different carbon sources are metabolized in parallel or
sequentially. Although described as a paradigm of the regulation of
bacterial metabolism, the underlying mechanisms remain controversial.
The models in the ensemble can be categorized according to regulatory,
stoichiometric, and physiological constraints and differ from each
other on only a single aspect. We distinguish four groups of models:
(1) flux balance models that only define reaction kinetics for
substrate uptake and by-product excretion, (2) kinetic models without
and (3) kinetic models with regulation on the metabolic and/or genetic
level, and (4) resource allocation models.
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